Usb mic or audio interface

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My question is: What can I do to eliminate or lessen the noise? Is it a problem with the computer, is it a fixable grounding issue (HDMI clue), or something else? Interestingly, I have observed that the noise is much worse/louder when I unplug my HDMI monitor. I hear a constant high-pitched background noise in my Behringer monitors, as well as cpu noises when I move my mouse etc. I recently got an Acer Aspire desktop, and am having issues using it with my M-Audio M-Tack usb interface.